Mouse Shb Antibody (C-term) [APR04408G]

Mouse Shb Antibody (C-term) [APR04408G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This Mouse Shb antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-95 amino acids from the C-terminal region of mouse Shb.

Cellular Localisation: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membrane lipid rafts upon TCR stimulation.

Molecular Weight: 54708

Clone: Polyclonal

Gene Name: Shb

Gene ID: 230126

Function: Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin- producing cells (By similarity) .

Summary: Tissue Location: Expressed in heart, liver, brain and kidney (at protein level) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: SH2 domain-containing adapter protein B, Shb