(Mouse) Sox15 Antibody (C-term) [APR32967G]

(Mouse) Sox15 Antibody (C-term) [APR32967G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This (Mouse) Sox15 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 152-165 amino acids from the C-terminal region of human (Mouse) Sox15.

Cellular Localisation: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:10821863, ECO:0000269|PubMed:15367664, ECO:0000269|PubMed:17363903}

Molecular Weight: 25311

Clone: Polyclonal

Gene Name: Sox15

Gene ID: 20670

Function: Transcription factor that binds to DNA at the 5'-AACAATG-3' consensus sequence (PubMed:10821863, PubMed:15863505, PubMed:16759287, PubMed:17363903) . Acts as a transcriptional activator and repressor (PubMed:10821863, PubMed:15863505, PubMed:16759287) . Binds synergistically with POU5F1 (OCT3/4) to gene promoters (PubMed:15863505) . Binds to the FOXK1 promoter and recruits FHL3, resulting in transcriptional activation of FOXK1 which leads to myoblast proliferation (PubMed:17363903) . Acts as an inhibitor of myoblast differentiation via transcriptional repression which leads to down-regulation of the muscle-specific genes MYOD and MYOG (PubMed:10821863) . Involved in trophoblast giant cell differentiation via enhancement of HAND1 transcriptional activity (PubMed:16759287) . Regulates transcription of HRC via binding to it proximal enhancer region (PubMed:15863505) . Involved in skeletal muscle regeneration (PubMed:15367664, PubMed:17363903) . Also plays a role in the development of myogenic precursor cells (PubMed:15367664) .

Summary: Tissue Location: Expressed in myoblasts (at protein level) (PubMed:15367664) . Expressed in embryonic stem cells (at protein level) (PubMed:15367664, PubMed:15863505) . Expressed in myogenic progenitor cells (at protein level) (PubMed:17363903) . Expressed in the ovary (PubMed:15367664) . Expressed in kidney, liver, skeletal muscle, and testes (PubMed:10821863, PubMed:15367664) . Expressed in lung and skin (PubMed:15863505) . Expressed in the brain, heart, diaphragm, and intestines (PubMed:10821863) . Expressed in the conceptus tissues of the placenta (PubMed:16759287) .

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Protein SOX-15, Sox15, Sox-15