(Mouse) Sox17 Antibody (C-term) [APR14741G]

(Mouse) Sox17 Antibody (C-term) [APR14741G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This (Mouse) Sox17 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 376-409 amino acids from the C-terminal region of mouse Sox17.

Cellular Localisation: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:20802155, ECO:0000269|PubMed:24153254, ECO:0000269|PubMed:8636240}

Molecular Weight: 44646

Clone: Polyclonal

Gene Name: Sox17

Gene ID: 20671

Function: Acts as transcription regulator that binds target promoter DNA and bends the DNA (PubMed:8636240, PubMed:24153254, PubMed:19328208) . Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3' (PubMed:8636240) . Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development (PubMed:11973269, PubMed:17655922, PubMed:24153254) . Required for normal development of the definitive gut endoderm (PubMed:11973269) . Required for normal looping of the embryonic heart tube. Plays an important role in embryonic and postnatal vascular development, including development of arteries (PubMed:24153254) . Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX18 (PubMed:16895970) . Required for the generation and maintenance of fetal hematopoietic stem cells, and for fetal hematopoiesis (PubMed:17655922) . Probable transcriptional activator in the premeiotic germ cells.

Summary: Tissue Location: Detected in lung and testis (PubMed:8636240) . Detected in endothelial cells around small and large arteries in newborns and adults, but is barely detectable in veins (at protein level) (PubMed:24153254) . Detected in lung and testis (PubMed:8636240)

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Transcription factor SOX-17, Sox17, Sox-17