(Mouse) Sox2 Antibody (N-term) [APR11357G]

(Mouse) Sox2 Antibody (N-term) [APR11357G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This Mouse Sox2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 6~39 amino acids from the N-terminal region of mouse sox2.

Cellular Localisation: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:17097055, ECO:0000269|PubMed:32127020}

Molecular Weight: 34454

Clone: Polyclonal

Gene Name: Sox2

Gene ID: 20674

Function: Transcription factor that forms a trimeric complex with POU5F1 (OCT3/4) on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (PubMed:15863505, PubMed:17097055, PubMed:19740739) . Binds to the proximal enhancer region of NANOG (PubMed:15863505) . Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity) . Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (PubMed:22198669) . Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity) . May function as a switch in neuronal development (By similarity) .

Summary: Tissue Location: Expressed in the cochlea (at protein level) (PubMed:32127020) . Expressed in the brain and retina (PubMed:7590241, PubMed:15863505) . A very low level of expression is seen in the stomach and lung (PubMed:7590241, PubMed:15863505) . Expressed in the kidney (PubMed:15863505) .

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Transcription factor SOX-2, Sox2, Sox-2