(Mouse) Srf Antibody (C-term) [APR04708G]

(Mouse) Srf Antibody (C-term) [APR04708G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M, Rat

Specificity: This (Mouse) Srf antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 489-524 amino acids from the C-terminal region of human (Mouse) Srf.

Cellular Localisation: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251, ECO:0000269|PubMed:19350017}

Molecular Weight: 51247

Clone: Polyclonal

Gene Name: Srf

Gene ID: 20807

Function: SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS) (PubMed:24732378) . Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:12732141, PubMed:19350017, PubMed:24732378) . The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G- actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics (PubMed:24732378) . Required for cardiac differentiation and maturation (PubMed:15169892) .

Summary: N/A

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Serum response factor, SRF, Srf