MPEP hydrochloride | B1151

MPEP hydrochloride is a highly selective and potent non-competitive antagonist at the mGlu5 (metabotropic glutamate receptor subtype 5) receptor subtype (IC₅₀ = 36 nM). It is a positive allosteric modulator at mGlu4. MPEP hydrochloride reduces DHPG (S-3, 5-dihydroxyphenylglycine)-induced excitations but not the excitations induced by AMPA (-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid). In vivo studies show it reverses mechanical hyperalgesia in the inflamed rat hind paw.

MPEP hydrochloride is a highly selective and potent non-competitive antagonist at the mGlu5 (metabotropic glutamate receptor subtype 5) receptor subtype (IC₅₀ = 36 nM). It is a positive allosteric modulator at mGlu4. MPEP hydrochloride reduces DHPG (S-3, 5-dihydroxyphenylglycine)-induced excitations but not the excitations induced by AMPA (-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid). In vivo studies show it reverses mechanical hyperalgesia in the inflamed rat hind paw.

B1151 | MPEP hydrochloride DataSheet

Alternate Name/Synonyms: 2-Methyl-6-(phenylethynyl)pyridine hydrochloride

Appearance: White Solid

Formulation: N/A

CAS Number: 219911-35-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: Yes

Molecular Formula: C₁₄H₁₁N.HCl

Molecular Weight: 229.71

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>20 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A highly selective and potent non-competitive antagonist at the mGlu5

MDL Number: MFCD02262119

PubChem CID: 9794588

SMILES: CC1=CC=CC(=N1)C#CC2=CC=CC=C2.Cl

InChi: 1S/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h2-9H,1H3;1H

InChi Key: PKDHDJBNEKXCBI-UHFFFAOYSA-N