MPZ polyclonal Antibody | BS6670

MPZ polyclonal Antibody | BS6670 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB 1:500 - 1:2000

Background: Zero, also known as myelin protein zero (MPZ) is a Type 1 integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath in order to ensure stable synaptic transmission. Zero protein encompasses approximately 50% of total protein in the sheath scaffolding in contribution to structural integrity of peripheral myelin. Zero guides the compact myelin wrapping process through glycine zipper packing interface-dependent dimer and tetramer formation. Mutations (e.g. G134R) can abrogate multimer formation, cause demyelinating neuropathies, and are known to contribute to conditions that include Charcot-Marie-Tooth disease. Zero cytoplasmic domain undergoes serine and tyrosine phosphorylation, which appears to be prevalent during peak nerve myelination. Zero transcript is moderate in brain, abundant in thymus and most abundant in white matter of the CNS.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: MPZ polyclonal Antibody detects endogenous levels of MPZ protein.

Molecular Weight: ~ 27 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Myelin protein P0; Myelin peripheral protein; MPP; Myelin protein zero

Immunogen: Recombinant full length Human MPZ.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: