MRAP2 Antibody (Center) [AMM06462G]

MRAP2 Antibody (Center) [AMM06462G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This MRAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the Central region of human MRAP2.

Cellular Localisation: Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context.

Molecular Weight: 23548

Clone: Polyclonal

Gene Name: MRAP2

Gene ID: 112609

Function: Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand- sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity) . May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R) ; however, additional evidence is required in vivo.

Summary: Tissue Location: Expressed in the adrenal gland and brain. Not expressed in other tissues.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Melanocortin-2 receptor accessory protein 2, MC2R accessory protein 2, MRAP2, C6orf117