MRPL18 polyclonal Antibody | BS61530

MRPL18 polyclonal Antibody | BS61530 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB

Application Range: WB: 1:500~1:1000

Background: Mitochondrial ribosomes consist of a large 39S subunit and a small 28S subunit, both of which are comprised of multiple mitochondrial ribosomal proteins (MRPs) that are encoded by nuclear genes and are essential for protein synthesis within mitochondria. MRP-L18 (mitochondrial ribosomal protein L18), also known as L18mt or HSPC071, is a 180 amino acid protein that localizes to the mitochondrion, where it exists as a component of the 39S ribosomal subunit and works in conjunction with MRPs to mediate protein synthesis. The gene encoding MRP-L18 maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: MRPL18 polyclonal Antibody detects endogenous levels of MRPL18 protein.

Molecular Weight: ~ 20 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: 39S ribosomal protein L18, mitochondrial; L18mt; MRP-L18

Immunogen: Synthetic peptide, corresponding to amino acids 7-51 of Human MRPL18.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 96% (by SDS-PAGE) .

Pathway: