MRX-2843 | B3388

MRX-2843 | B3388

Description: MRX-2843 (UNC2371) is a potent, ATP-competitive dual MERTK and FLT3 tyrosine kinases inhibitor (TKI) with enzymatic IC50s of 1.3 nM for MERTK and 0.64 nM for FLT3, respectively. It also inhibits Axl and Tyro3 (IC50s = 15 and 17 nM, respectively). MRX-2843 (10-300 nM) inhibits Mer phosphorylation in MOLM-14 and MV4-11 acute myeloid leukemia (AML) cells and reduces clonal expansion of Kasumi-1 AML cells (IC50 = 143.5 nM).

Alternate Name/Synonyms: trans-4-[2-[(2-cyclopropylethyl)amino]-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclohexanol

Appearance: Solid

Formulation:

CAS Number: 1429882-07-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₉H₄₀N₆O

Molecular Weight: 488.67

Cell-Permeable?: True

Purity: ≥98%

Solubilities: < DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Tag Line: An inhibitor of Mer and FMS-like tyrosine kinase 3

MDL Number:

PubChem CID: 89495685

PubChem CID Link: https://pubchem.ncbi.nlm.nih.gov/compound/89495685

SMILES: CN1CCN(CC1)CC2=CC=C(C=C2)C3=CN(C4=NC(=NC=C34)NCCC5CC5)C6CCC(CC6)O

InChi: InChI=1S/C29H40N6O/c1-33-14-16-34(17-15-33)19-22-4-6-23(7-5-22)27-20-35(24-8-10-25(36)11-9-24)28-26(27)18-31-29(32-28)30-13-12-21-2-3-21/h4-7,18,20-21,24-25,36H,2-3,8-17,19H2,1H3,(H,30,31,32)

InChi Key: LBEJYFVJIPQSNX-UHFFFAOYSA-N

Category: Biochemicals