MS-275 (Entinostat, SNDX-275) | 1590

Preferentially inhibits HDAC1 (IC₅₀ = 300 nM) over HDAC3 (IC₅₀ = 8 µM). Has no inhibitory activity towards HDAC8 (IC₅₀>100 µM).

MS-275 (Entinostat, SNDX-275) preferentially inhibits HDAC1 (IC₅₀ = 300 nM) over HDAC3 (IC₅₀ = 8 µM). Has no inhibitory activity towards HDAC8 (IC₅₀>100 µM).

1590 | MS-275 (Entinostat, SNDX-275) DataSheet

Alternate Name/Synonyms: Entinostat, SNDX-275

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 209783-80-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₀N₄O₃

Molecular Weight: 376.41

Cell-Permeable?: Yes

Purity: ≥99% by HPLC

Solubilities: DMSO (38 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A HDAC1 and HDAC3 inhibitor

MDL Number: MFCD08272435

PubChem CID: 4261

SMILES: C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3

InChi: InChI=1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13- 24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)

InChi Key: INVTYAOGFAGBOE-UHFFFAOYSA-N