MS023 | B2575

MS023 is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) (IC₅₀s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively). MS023 is completely inactive against type II and type III PRMTs, protein lysine methyltransferases and DNA methyltransferases.

MS023 is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) (IC₅₀s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively). MS023 is completely inactive against type II and type III PRMTs, protein lysine methyltransferases and DNA methyltransferases.

B2575 | MS023 DataSheet

Alternate Name/Synonyms: N1-((4-(4-isopropoxyphenyl)-1H-pyrrol-3-yl)methyl)-N1-methylethane-1,2-diamine, MS-023

Appearance: Crystalline solid

Formulation:

CAS Number: 1831110-54-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₂₅N₃O

Molecular Weight: 287.41

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >25 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: Type I Protein Arginine Methyltransferases inhibitor

MDL Number:

PubChem CID: 92136227

SMILES: CC(C)OC1=CC=C(C=C1)C2=CNC=C2CN(C)CCN

InChi: InChI=1S/C17H25N3O/c1-13(2)21-16-6-4-14(5-7-16)17-11-19-10-15(17)12-20(3)9-8-18/h4-7,10-11,13,19H,8-9,12,18H2,1-3H3

InChi Key: FMTVWAGUJRUAKE-UHFFFAOYSA-N