Description
MS023 is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) (IC₅₀s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively). MS023 is completely inactive against type II and type III PRMTs, protein lysine methyltransferases and DNA methyltransferases.
MS023 is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) (IC₅₀s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively). MS023 is completely inactive against type II and type III PRMTs, protein lysine methyltransferases and DNA methyltransferases.
Alternate Name/Synonyms: N1-((4-(4-isopropoxyphenyl)-1H-pyrrol-3-yl)methyl)-N1-methylethane-1,2-diamine, MS-023
Appearance: Crystalline solid
Formulation:
CAS Number: 1831110-54-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₇H₂₅N₃O
Molecular Weight: 287.41
Cell-Permeable?: True
Purity: ≥98% by HPLC
Solubilities: >25 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: Type I Protein Arginine Methyltransferases inhibitor
MDL Number:
PubChem CID: 92136227
SMILES: CC(C)OC1=CC=C(C=C1)C2=CNC=C2CN(C)CCN
InChi: InChI=1S/C17H25N3O/c1-13(2)21-16-6-4-14(5-7-16)17-11-19-10-15(17)12-20(3)9-8-18/h4-7,10-11,13,19H,8-9,12,18H2,1-3H3
InChi Key: FMTVWAGUJRUAKE-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |