Description
MS37452 is a competitive inhibitor of CBX7 (Chromobox homolog 7) chromodomain binding to trimethylated lysine 27 of histone 3 (H3K27me3). It inhibits CBX7-H3K27me3 binding with a Ki of 43.0 μM. At 250 µM, it derepresses transcription of Polycomb repressive complex target gene p16/CDKN2A by displacing CBX7 binding to the INK4A/ARF locus in PC3 prostate cancer cells.
MS37452 is a competitive inhibitor of CBX7 (Chromobox homolog 7) chromodomain binding to trimethylated lysine 27 of histone 3 (H3K27me3). It inhibits CBX7-H3K27me3 binding with a Ki of 43.0 μM. At 250 µM, it derepresses transcription of Polycomb repressive complex target gene p16/CDKN2A by displacing CBX7 binding to the INK4A/ARF locus in PC3 prostate cancer cells.
Alternate Name/Synonyms: 1-[4-(2,3-dimethoxybenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethanone; 1-(2,3-dimethoxybenzoyl)-4-[(3-methylphenoxy)acetyl]piperazine; 1-(4-(2,3-Dimethoxybenzoyl)piperazin-1-yl)-2-(m-tolyloxy)ethanone; 1-{4-[(2,3-dimethoxyphenyl)carbonyl]piperazin-1-yl}-2-(3-methylphenoxy)ethanone
Appearance: A crystalline solid
Formulation:
CAS Number: 423748-02-1
Structure Available?: True
Peptide sequence:
Salt Form: false
Molecular Formula: C₂₂H₂₆N₂O₅
Molecular Weight: 398.45
Cell-Permeable?: True
Purity: ≥98%
Solubilities: ~30 mg/ml in ethanol, DMSO and DMF in 0
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An inhibitor of CBX7 chromodomain binding to H3K27me3
MDL Number:
PubChem CID: 1072048
SMILES: CC1=CC(=CC=C1)OCC(=O)N2CCN(CC2)C(=O)C3=C(C(=CC=C3)OC)OC
InChi: InChI=1S/C22H26N2O5/c1-16-6-4-7-17(14-16)29-15-20(25)23-10-12-24(13-11-23)22(26)18-8-5-9-19(27-2)21(18)28-3/h4-9,14H,10-13,15H2,1-3H3
InChi Key: LUMCNRKHZRYQOV-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
RT |
Shelf Life: |
36 months |