MSC-2530818 | B1975

MSC-2530818 is a potent, selective CDK8 Inhibitor (IC₅₀ = 2.6 nM). It displays potent inhibition of phospho-STAT1SER727, an established biomarker of CDK8 activity. MSC2530818 demonstrates potent inhibition of WNT-dependent transcription in human cancer cell lines that have constitutively activated WNT signaling.

MSC-2530818 is a potent, selective CDK8 Inhibitor (IC₅₀ = 2.6 nM). It displays potent inhibition of phospho-STAT1SER727, an established biomarker of CDK8 activity. MSC2530818 demonstrates potent inhibition of WNT-dependent transcription in human cancer cell lines that have constitutively activated WNT signaling.

B1975 | MSC-2530818 DataSheet

Alternate Name/Synonyms: [(2S)-2-(4-Chlorophenyl)pyrrolidin-1-yl]-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1883423-59-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₇ClN₄O

Molecular Weight: 340.81

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, selective CDK8 Inhibitor

MDL Number: N/A

PubChem CID: 118879529

SMILES: CC1=C2C=C(C=NC2=NN1)C(=O)N3CCCC3C4=CC=C(C=C4)Cl

InChi: InChI=1S/C18H17ClN4O/c1-11-15-9-13(10-20-17(15)22-21-11)18(24)23-8-2-3-16(23)12-4-6-14(19)7-5-12/h4-7,9-10,16H,2-3,8H2,1H3,(H,20,21,22)/t16-/m0/s1

InChi Key: ODRITQGYYWHQGM-INIZCTEOSA-N