MSH6 polyclonal Antibody | BS90882

MSH6 polyclonal Antibody | BS90882 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Application: WB IHC IP

Application Range: WB:1:500-1:2,000 IHC:1:50-1:200 IP:1:10-1:50

Background: Component of the post-replicative DNA mismatch repair system (MMR) . Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP>ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: MSH6 polyclonal Antibody detects endogenous levels of MSH6 protein.

Molecular Weight: 153 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: hMSH6, GTBP, GTMBP, p160, MSH6, DNA mismatch repair protein Msh6, G/T mismatch binding protein, G/T mismatch-binding protein, GTBP, GTMBP, hMSH6, HNPCC 5, HNPCC5, HSAP, MSH 6, MSH6, MSH6, mutS (E. coli) homolog 6, MutS alpha 160 kDa subunit, MutS homolog 6 (E. coli), mutS homolog 6, MutS-alpha 160 kDa subunit, p160, Sperm associated protein,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: