MSL1 Antibody (Center) [APR31240G]

MSL1 Antibody (Center) [APR31240G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This MSL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 339-367 amino acids from the Central region of human MSL1.

Cellular Localisation: Nucleus. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q6PDM1}. Nucleus speckle {ECO:0000250|UniProtKB:Q6PDM1}

Molecular Weight: 67128

Clone: Polyclonal

Gene Name: MSL1

Gene ID: 339287

Function: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure (PubMed:16227571) . Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816) . This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816) . In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Male-specific lethal 1 homolog, MSL-1, Male-specific lethal 1-like 1, MSL1-like 1, Male-specific lethal-1 homolog 1, MSL1, MSL1L1