MTF2 Antibody (Center) [APR31651G]

MTF2 Antibody (Center) [APR31651G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M, Rat

Specificity: This MTF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 289-317 amino acids from the Central region of human MTF2.

Cellular Localisation: Nucleus. Note=Localizes to chromatin as part of the PRC2 complex

Molecular Weight: 67090

Clone: Polyclonal

Gene Name: MTF2

Gene ID: 22823

Function: Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:23142980, PubMed:23228662, PubMed:31959557) . Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation (By similarity) . Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells (By similarity) . Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex (By similarity) . In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally (By similarity) . Binds to the metal- regulating-element (MRE) of MT1A gene promoter (By similarity) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Metal-response element-binding transcription factor 2, Metal regulatory transcription factor 2, Metal-response element DNA-binding protein M96, Polycomb-like protein 2, hPCl2, MTF2, PCL2