MTM1 Antibody (C-term) [APR05808G]

MTM1 Antibody (C-term) [APR05808G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This MTM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 566-594 amino acids from the C-terminal region of human MTM1.

Cellular Localisation: Cytoplasm. Cell membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Late endosome. Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:Q9Z2C5}. Note=Localizes as a dense cytoplasmic network (PubMed:11001925) . Also localizes to the plasma membrane, including plasma membrane extensions such as filopodia and ruffles (PubMed:12118066) . Predominantly located in the cytoplasm following interaction with MTMR12 (PubMed:12847286) . Recruited to the late endosome following EGF stimulation (PubMed:14722070) . In skeletal muscles, co-localizes with MTMR12 in the sarcomere (By similarity) {ECO:0000250|UniProtKB:Q9Z2C5, ECO:0000269|PubMed:11001925, ECO:0000269|PubMed:12118066, ECO:0000269|PubMed:12847286, ECO:0000269|PubMed:14722070}

Molecular Weight: 69932

Clone: Polyclonal

Gene Name: MTM1 (HGNC:7448)

Gene ID: 4534

Function: Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3, 5-bisphosphate (PI (3, 5) P2) (PubMed:11001925, PubMed:10900271, PubMed:12646134, PubMed:14722070) . Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides (PubMed:9537414) . Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome (PubMed:14722070) . Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture (PubMed:21135508) . Plays a role in mitochondrial morphology and positioning (PubMed:21135508) . Required for skeletal muscle maintenance but not for myogenesis (PubMed:21135508) . In skeletal muscles, stabilizes MTMR12 protein levels (PubMed:23818870) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Myotubularin, Phosphatidylinositol-3, 5-bisphosphate 3-phosphatase, Phosphatidylinositol-3-phosphate phosphatase, MTM1, CG2