MTMR9 Antibody [APR05807G]

MTMR9 Antibody [APR05807G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This MTMR8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 518-549 amino acids from the C-terminal region of human MTMR8.

Cellular Localisation: Cytoplasm. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q9Z2D0}; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region Endoplasmic reticulum. Note=Localizes to ruffles during EGF-induced macropinocytosis (By similarity) Colocalizes with MTMR6 to the perinuclear region (PubMed:19038970) Partially localizes to the endoplasmic reticulum (PubMed:19038970) {ECO:0000250|UniProtKB:Q9Z2D0, ECO:0000269|PubMed:19038970}

Molecular Weight: 63462

Clone: Polyclonal

Gene Name: MTMR9

Gene ID: 66036

Function: Acts as an adapter for myotubularin-related phosphatases (PubMed:19038970, PubMed:22647598) . Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3, 5- bisphosphate and MTMR6 binding affinity for phosphorylated phosphatidylinositols (PubMed:19038970, PubMed:22647598) . Positively regulates lipid phosphatase MTMR7 catalytic activity (By similarity) . Increases MTMR8 catalytic activity towards phosphatidylinositol 3- phosphate (PubMed:22647598) . The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970) . Stabilizes MTMR8 protein levels (PubMed:22647598) . Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580) . Negatively regulates autophagy, in part via its association with MTMR8 (PubMed:22647598) . Negatively regulates DNA damage-induced apoptosis, in part via its association with MTMR6 (PubMed:19038970, PubMed:22647598) . Does not bind mono-, di- and tri- phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine (PubMed:19038970) .

Summary: Tissue Location: Expressed in many tissues.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Myotubularin-related protein 9, 313-, MTMR8