mTOR Inhibitor, Ku-0063794 | 1779

A potent mTOR (mammalian target of rapamycin) inhibitor (IC₅₀ = ~10 nM for mTORC1 and mTORC2, respectively). Displays no activity against PI 3-kinase or 76 other kinases tested.

Ku-0063794 is a potent mTOR (mammalian target of rapamycin) inhibitor (IC₅₀ = ~10 nM for mTORC1 and mTORC2, respectively). Displays no activity against PI 3-kinase or 76 other kinases tested.

1779 | mTOR Inhibitor, Ku-0063794 DataSheet

Alternate Name/Synonyms: rel-5-[2-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol

Appearance: Pale yellow solid

Formulation: N/A

CAS Number: 938440-64-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₃₁N₅O₄

Molecular Weight: 465.54

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A mTOR inhibitor

MDL Number: MFCD11977741

PubChem CID: 16736978

SMILES: CC1CN(CC(O1)C)C2=NC3=C(C=CC(=N3)C4=CC(=C(C=C4)OC)CO)C(=N2)N5CCOCC5

InChi: InChI=1S/C25H31N5O4/c1-16-13-30(14-17(2)34-16)25-27-23-20(24(28-25)29-8-10-33-11-9-29)5-6-21(26-23)18-4-7-22(32-3)19(12-18)15-31/h4-7,12,16-17,31H,8-11,13-15H2,1-3H3/t16-,17+

InChi Key: RFSMUFRPPYDYRD-CALCHBBNSA-N