mTOR Inhibitor, WYE-28 | 2255

Cell-permeable. A potent, selective, and ATP-competitive mTOR (mammalian Target Of Rapamycin) inhibitor (IC₅₀ = 0.08 nM). Displays 75-fold selectivity over PI3Kα (IC₅₀ = 6 nM).

WYE-28 is a potent, selective, and ATP-competitive mTOR (mammalian Target Of Rapamycin) inhibitor (IC₅₀ = 0.08 nM). Displays 75-fold selectivity over PI3Kα (C₅₀ = 6 nM).

2255 | mTOR Inhibitor, WYE-28 DataSheet

Alternate Name/Synonyms: 4-(6-{4-[3-(4-Hydroxymethyl-phenyl)-ureido]-phenyl}-4-morpholin-4-yl-pyrazolo[3,4-d]pyrimidin-1-yl)-piperidine-1-carboxylic acid methyl ester

Appearance: White solid

Formulation: N/A

CAS Number: 1062172-60-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₀H₃₄N₈O₅

Molecular Weight: 586.64

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>60 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A selective, picomolar-potent mTOR inhibitor

MDL Number: N/A

PubChem CID: 24936050

SMILES: COC(=O)N1CCC(CC1)N2C3=C(C=N2)C(=NC(=N3)C4=CC=C(C=C4)NC(=O)NC5=CC=C(C=C5)CO)N6CCOCC6

InChi: InChI=1S/C30H34N8O5/c1-42-30(41)37-12-10-24(11-13-37)38-28-25(18-31-38)27(36-14-16-43-17-15-36)34-26(35-28)21-4-8-23(9-5-21)33-29(40)32-22-6-2-20(19-39)3-7-22/h2-9,18,24,39H,10-17,19H2,1H3,(H2,32,33,40)

InChi Key: DLIGFKRUAOAIBA-UHFFFAOYSA-N