MX1013 | B2588

MX-1013, as a potent, irreversible dipeptide caspase inhibitor. It inhibits caspases 1, 3, 6, 7, 8, and 9, with IC₅₀ values ranging from 5 to 20 nm. MX1013 is selective for caspases, and is a poor inhibitor of non-caspase proteases, such as cathepsin B, calpain I, or Factor Xa (IC₅₀ values >10 µM).

MX-1013, as a potent, irreversible dipeptide caspase inhibitor. It inhibits caspases 1, 3, 6, 7, 8, and 9, with IC₅₀ values ranging from 5 to 20 nm. MX1013 is selective for caspases, and is a poor inhibitor of non-caspase proteases, such as cathepsin B, calpain I, or Factor Xa (IC₅₀ values >10 µM).

B2588 | MX1013 DataSheet

Alternate Name/Synonyms: MX-1013, Z-VAL-DL-ASP-FLUOROMETHYLKETONE, MX 1013, 3-((S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanamido)-5-fluoro-4-oxopentanoic acid, Z-VD-FMK

Appearance: Lyophilized solid

Formulation:

CAS Number: 582316-00-5

Structure Available?: Yes

Peptide sequence: Z-VD-FMK

Salt Form: No

Molecular Formula: C₁₈H₂₃FN₂O₆

Molecular Weight: 382.39

Cell-Permeable?: True

Purity: ≥95% by HPLC

Solubilities: in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A dipeptide caspase inhibitor

MDL Number:

PubChem CID: 9821317

SMILES: CC(C)C(C(=O)NC(CC(=O)O)C(=O)CF)NC(=O)OCC1=CC=CC=C1

InChi: InChI=1S/C18H23FN2O6/c1-11(2)16(17(25)20-13(8-15(23)24)14(22)9-19)21-18(26)27-10-12-6-4-3-5-7-12/h3-7,11,13,16H,8-10H2,1-2H3,(H,20,25)(H,21,26)(H,23,24)/t13?,16-/m0/s1

InChi Key: