Myeloperoxidase Inhibitor | 1977

A potent, irreversible, and specific inhibitor of the peroxidation activity of myeloperoxidase (MPO; IC₅₀ = 300 nM). Does not affect catalase or glutathione peroxidase activities. Also displays no effect on the production of superoxide by neutrophils. Shown to inhibit H₂O₂-induced apoptosis in HL-60, human leukemia cells.

Myeloperoxidase Inhibitor is a potent, irreversible, and specific inhibitor of the peroxidation activity of myeloperoxidase (MPO; IC₅₀ = 300 nM). Does not affect catalase or glutathione peroxidase activities. Also displays no effect on the production of superoxide by neutrophils. Shown to inhibit H₂O₂-induced apoptosis in HL-60, human leukemia cells.

1977 | Myeloperoxidase Inhibitor DataSheet

Alternate Name/Synonyms: 4-Aminobenzoic hydrazide; MPO Inhibitor; 4-ABH

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 5351-17-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₇H9N₃O

Molecular Weight: 151.17

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO

Handling: Protect from light and mositure

Country of Origin: USA

Tag Line: A potent myeloperoxidase (MPO) inhibitor

MDL Number: MFCD00007606

PubChem CID: 21450

SMILES: C1=CC(=CC=C1C(=O)NN)N

InChi: InChI=1S/C7H9N3O/c8-6-3-1-5(2-4-6)7(11)10-9/h1-4H,8-9H2,(H,10,11)

InChi Key: WPBZMCGPFHZRHJ-UHFFFAOYSA-N