Description
MYK-461 is an orally active inhibitor of cardiac myosin ATPase (IC50 = 0.3 µM in purified bovine myosin S1). It displays selectivity for cardiac myosin over skeletal myosin (IC50 = 4.7 µM) and does not induce skeletal muscle impairments. Formulations containing MYK-461 have been used for the treatment of symptomatic hypertrophic cardiomyopathy in humans and cats.
MYK-461 is an orally active inhibitor of cardiac myosin ATPase (IC50 = 0.3 µM in purified bovine myosin S1). It displays selectivity for cardiac myosin over skeletal myosin (IC50 = 4.7 µM) and does not induce skeletal muscle impairments. Formulations containing MYK-461 have been used for the treatment of symptomatic hypertrophic cardiomyopathy in humans and cats.
Alternate Name/Synonyms: 3-(1-methylethyl)-6-[[(1S)-1-phenylethyl]amino]-2,4(1H,3H)-pyrimidinedione,SAR439152
Appearance: Crystalline solid
Formulation:
CAS Number: 1642288-47-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₅H₁₉N₃O₂
Molecular Weight: 273.3
Cell-Permeable?: TRUE
Purity: ≥98%
Solubilities: >20 mg/ml DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An orally active inhibitor of cardiac myosin ATPase
MDL Number:
PubChem CID: 117761397
SMILES: O=C1N(C(C)C)C(NC(N[C@@H](C)C2=CC=CC=C2)=C1)=O
InChi: InChI=1S/C15H19N3O2/c1-10(2)18-14(19)9-13(17-15(18)20)16-11(3)12-7-5-4-6-8-12/h4-11,16H,1-3H3,(H,17,20)/t11-/m0/s1
InChi Key: RLCLASQCAPXVLM-NSHDSACASA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |