MYK-461 | B3229

MYK-461 is an orally active inhibitor of cardiac myosin ATPase (IC50 = 0.3 µM in purified bovine myosin S1). It displays selectivity for cardiac myosin over skeletal myosin (IC50 = 4.7 µM) and does not induce skeletal muscle impairments. Formulations containing MYK-461 have been used for the treatment of symptomatic hypertrophic cardiomyopathy in humans and cats.

MYK-461 is an orally active inhibitor of cardiac myosin ATPase (IC50 = 0.3 µM in purified bovine myosin S1). It displays selectivity for cardiac myosin over skeletal myosin (IC50 = 4.7 µM) and does not induce skeletal muscle impairments. Formulations containing MYK-461 have been used for the treatment of symptomatic hypertrophic cardiomyopathy in humans and cats.

B3229 | MYK-461 DataSheet

Alternate Name/Synonyms: 3-(1-methylethyl)-6-[[(1S)-1-phenylethyl]amino]-2,4(1H,3H)-pyrimidinedione,SAR439152

Appearance: Crystalline solid

Formulation:

CAS Number: 1642288-47-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₁₉N₃O₂

Molecular Weight: 273.3

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: >20 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An orally active inhibitor of cardiac myosin ATPase

MDL Number:

PubChem CID: 117761397

SMILES: O=C1N(C(C)C)C(NC(N[C@@H](C)C2=CC=CC=C2)=C1)=O

InChi: InChI=1S/C15H19N3O2/c1-10(2)18-14(19)9-13(17-15(18)20)16-11(3)12-7-5-4-6-8-12/h4-11,16H,1-3H3,(H,17,20)/t11-/m0/s1

InChi Key: RLCLASQCAPXVLM-NSHDSACASA-N