MYSM1 Antibody (N-term) [APR30625G]

MYSM1 Antibody (N-term) [APR30625G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This MYSM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-139 amino acids from the N-terminal region of human MYSM1.

Cellular Localisation: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:17707232}. Cytoplasm {ECO:0000250|UniProtKB:Q69Z66} Note=Localizes to the cytoplasm in response to bacterial infection {ECO:0000250|UniProtKB:Q69Z66}

Molecular Weight: 95032

Clone: Polyclonal

Gene Name: MYSM1

Gene ID: 114803

Function: Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response (PubMed:24062447, PubMed:26220525, PubMed:28115216) . Participates in the normal programming of B-cell responses to antigen after the maturation process (By similarity) . Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity (PubMed:33086059) . Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes (By similarity) . Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component (By similarity) . Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys- 63'-linked ubiquitin chains (PubMed:33086059) . In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors (PubMed:24062447) . Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome (PubMed:17707232) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: FC, WB

Dilution: WB--1:1000 FC--1:10~50

Synonyms: Histone H2A deubiquitinase MYSM1, 2A-DUB, 3419-, Myb-like, SWIRM and MPN domain-containing protein 1, MYSM1, KIAA1915