N-Cadherin polyclonal Antibody | BS90914

N-Cadherin polyclonal Antibody | BS90914 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Application: WB ICC IHC FC

Application Range: WB:1:500 ICC:1:200 IHC:1:200 FC:1:50

Background: The cadherins are a large family of cell adhesion molecules involved in calcium-dependent recognition and adhesion events. The cadherin subfamily includes N-, P-, B-, and E- cadherins, and other members. Recent studies indicate that cancer cells have up-regulated N-cadherin in addition to loss of E-cadherin. N-cadherin cooperates with the FGF receptor, leading to overexpression of MMP-9 and cellular invasion. N-Cadherin is commonly found in cancer cells and provides a mechanism for transendothelial migration. When a cancer cell adheres to the endothelial cells of a blood vessel it up-regulates the src kinase pathway, which phosphorylates beta-catenins attached to both N-cadherin (this protein) and E-cadherins.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: N-Cadherin polyclonal Antibody detects endogenous levels of N-Cadherin protein.

Molecular Weight: 140 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: N-cadherin, CADH2, CADH2, Cadherin 2, Cadherin 2 N cadherin neuronal, Cadherin 2 type 1, Cadherin 2 type 1 N cadherin neuronal, Cadherin 2, type 1, N-cadherin (neuronal), Cadherin-2, Cadherin2, Calcium dependent adhesion protein neuronal, CD325, CD325 antigen, CDH2, CDHN, CDw325, CDw325 antigen, N cadherin 1, N-cadherin, NCAD, Neural cadherin, OTTHUMP00000066304, OTTHUMP00000067378,

Immunogen: Synthetic peptide (KLH-coupled) within human N-cadherin 360-420 aa.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Peptide affinity purified

Pathway: Adherens Junction signaling,