N-Cadherin (W745) polyclonal Antibody | BS2224

N-Cadherin (W745) polyclonal Antibody | BS2224 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC IF

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background: Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2-terminal repeats. The most distal of these cadherins is thought to be responsible for binding specificity, transmembrane domains and carboxyterminal intracellular domains. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as β-catenin, to regulate cadherin function. Members of this family of adhesion proteins include rat cadherin K (and its human homolog, cadherin-6), R-cadherin, B-cadherin, E/P-cadherin and cadherin-5.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: N-cadherin (W745) polyclonal Antibody detects endogenous levels of N-cadherin protein.

Molecular Weight: ~ 100, 140 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Cadherin2; Cadherin 2; Cadherin-2; CDw325; Neural cadherin; N-cadherin; CD325; CDH2; CDHN; NCAD

Immunogen: Synthetic peptide, corresponding to amino acids 710-760 of Human N-Cadherin.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A