N4-Hydroxycytidine | B3039

N4-Hydroxycytidine is a ribonucleoside analog with broad-spectrum antiviral activity. The prodrug of N4-hydroxycytidine is EIDD-2801. N4-Hydroxycytidine is active against influenza, Ebola, Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)and Venezuelan equine encephalitis virus (VEEV). It inhibits replication of SARS-CoV-2 and Middle East respiratory syndrome coronavirus (MERS-CoV) in Calu-3 2B4 cells with IC₅₀ values of 0.08 μM and 0.15 μM respectively. N4-Hydroxycytidine (100 and 400 mg/kg twice per day) reduces lung viral titers in a mouse model of Respiratory Syncytial Virus (RSV) infection.

N4-Hydroxycytidine is a ribonucleoside analog with broad-spectrum antiviral activity. The prodrug of N4-hydroxycytidine is EIDD-2801. N4-Hydroxycytidine is active against influenza, Ebola, Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)and Venezuelan equine encephalitis virus (VEEV). It inhibits replication of SARS-CoV-2 and Middle East respiratory syndrome coronavirus (MERS-CoV) in Calu-3 2B4 cells with IC₅₀ values of 0.08 μM and 0.15 μM respectively. N4-Hydroxycytidine (100 and 400 mg/kg twice per day) reduces lung viral titers in a mouse model of Respiratory Syncytial Virus (RSV) infection.

B3039 | N4-Hydroxycytidine DataSheet

Alternate Name/Synonyms: EIDD-1931; NHC; Uridine, 4-oxime; Beta-D-N4-hydroxycytidine; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-hydroxyamino-1H-pyrimidin-2-one

Appearance: White solid

Formulation:

CAS Number: 496036

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₉H₁₃N₃O₆

Molecular Weight: 259.22

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~20 mg/ml in DMSO; ~10 mg/ml in PBS, pH7.2; ~10 mg/ml in DMF

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A ribonucleoside analog with broad-spectrum antiviral activity

MDL Number: MFCD01675695

PubChem CID: 197020

SMILES: C1=CN(C(=O)N=C1NO)C2C(C(C(O2)CO)O)O

InChi: InChI=1S/C9H13N3O6/c13-3-4-6(14)7(15)8(18-4)12-2-1-5(11-17)10-9(12)16/h1-2,4,6-8,13-15,17H,3H2,(H,10,11,16)/t4-,6-,7-,8-/m1/s1

InChi Key: XCUAIINAJCDIPM-XVFCMESISA-N