Na+ CP type α-pan (E1476) polyclonal Antibody | BS3558

Na+ CP type α-pan (E1476) polyclonal Antibody | BS3558 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: IHC

Application Range: IHC:1:50~1:200

Background: Voltage-gated Na+ channels regulate the permeability of excitable cells to sodium ions. During the propagation of an action potential, Na+ channels allow an influx of sodium ions, which rapidly depolarize the cell. The sodium channel protein is comprised of one α subunit and two β subunits. The Na+ CP type I and Na+ CP type IIα subunits are expressed in adult brain. Na+ CP type IIIα is expressed in embryonic brain, but not in adult brain. Na+ CP type IIIβ is a 215 amino acid, single-pass type I membrane protein that modulates sodium channel gating kinetics and inactivates the channel opening more slowly than the Iβ subunit. It has an extracellular N-terminal domain, an N-terminal signal sequence, a single membrane-spanning region and a C-terminal cytoplasmic region.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Na+ CP type α-pan (E1476) polyclonal Antibody detects endogenous levels of Na+ CP type α-pan protein.

Molecular Weight: ~ 226 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Sodium channel protein type 9 subunit alpha; Neuroendocrine sodium channel; hNE-Na; Peripheral sodium channel 1; PN1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7; SCN9A; NENA

Immunogen: Synthetic peptide, corresponding to amino acids 1442-1496 of Human Na+ CP type α-pan.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: