NACA Antibody | 13-442

NACA Antibody | 13-442 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human NACA (NP_001106673.1) .

Research Area: Other

Tested Application: WB, IHC, IP

Application: WB: 1:500 - 1:2000
IHC: 1:50 - 1:100
IP: 1:50 - 1:100

Specificiy: N/A

Positive Control 1: HL-60

Positive Control 2: SW620

Positive Control 3: 293T

Positive Control 4: U-87MG

Positive Control 5: HeLa

Positive Control 6: Mouse liver

Molecular Weight: Observed: 37kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: HSD48, NAC-alpha1, skNAC, NACA, nascent polypeptide-associated complex subunit alpha, alpha-NAC, muscle-specific form, nascent-polypeptide-associated complex alpha polypeptide

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC) . This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative splicing results in multiple transcript variants, but the full length nature of some of these variants, including those encoding very large proteins, has not been determined. There are multiple pseudogenes of this gene on different chromosomes.