Nafamostat Mesylate | 1760

A broad-spectrum, synthetic serine protease inhibitor and an inhibitor of the classical and alternative ways of complement activation. Displays selectivity for human tryptase when used at relatively low concentrations. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma.

Nafamostat Mesylate is a broad-spectrum, synthetic serine protease inhibitor and an inhibitor of the classical and alternative ways of complement activation. Displays selectivity for human tryptase when used at relatively low concentrations.

1760 | Nafamostat Mesylate DataSheet

Alternate Name/Synonyms: 4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester dimethanesulfonate; FUT-175; Futhan

Appearance: Off-white solid

Formulation: N/A

CAS Number: 82956-11-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₇N₅O₂.2CH₄O₃S

Molecular Weight: 539.59

Cell-Permeable?: Yes

Purity: ≥97% by HPLC

Solubilities: DMSO (100 mM) and H₂O (100 mM)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A broad spectrum serine protease inhibitor

MDL Number: MFCD00941430

PubChem CID: 5311180

SMILES: CS(=O)(=O)O.CS(=O)(=O)O.C1=CC(=CC=C1C(=O)OC2=CC3=C(C=C2)C=C(C=C3)C(=N)N)N=C(N)N

InChi: InChI=1S/C19H17N5O2.2CH4O3S/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23;2*1-5(2,3)4/h1-10H,(H3,20,21)(H4,22,23,24);2*1H3,(H,2,3,4)

InChi Key: SRXKIZXIRHMPFW-UHFFFAOYSA-N