Description
A broad-spectrum, synthetic serine protease inhibitor and an inhibitor of the classical and alternative ways of complement activation. Displays selectivity for human tryptase when used at relatively low concentrations. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma.
Nafamostat Mesylate is a broad-spectrum, synthetic serine protease inhibitor and an inhibitor of the classical and alternative ways of complement activation. Displays selectivity for human tryptase when used at relatively low concentrations.
1760 | Nafamostat Mesylate DataSheet
Alternate Name/Synonyms: 4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester dimethanesulfonate; FUT-175; Futhan
Appearance: Off-white solid
Formulation: N/A
CAS Number: 82956-11-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₉H₁₇N₅O₂.2CH₄O₃S
Molecular Weight: 539.59
Cell-Permeable?: Yes
Purity: ≥97% by HPLC
Solubilities: DMSO (100 mM) and H₂O (100 mM)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A broad spectrum serine protease inhibitor
MDL Number: MFCD00941430
PubChem CID: 5311180
SMILES: CS(=O)(=O)O.CS(=O)(=O)O.C1=CC(=CC=C1C(=O)OC2=CC3=C(C=C2)C=C(C=C3)C(=N)N)N=C(N)N
InChi: InChI=1S/C19H17N5O2.2CH4O3S/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23;2*1-5(2,3)4/h1-10H,(H3,20,21)(H4,22,23,24);2*1H3,(H,2,3,4)
InChi Key: SRXKIZXIRHMPFW-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |