NAGA polyclonal Antibody | BS71378

NAGA polyclonal Antibody | BS71378 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB,IF

Application Range: WB 1:500 - 1:2000 IF 1:50 - 1:200

Background: NAGA (N-acetylgalactosaminidase, α), also known as α-galactosidase B or GALB, is a 411 lysosomal protein belonging to the glycosyl hydrolase 27 family that may exist as a homodimer and plays a critical role in glycolipid breakdown. NAGA encodes α-N-acetylgalactosaminidase, a lysosomal enzyme, which cleaves α-N-acetylgalactosaminyl groups from glycoconjugates. Mapping to human chromosome 22q13.2, NAGA defects are the cause of an autosomal recessive disorder with three phenotypes, known as Schindler disease (types I, II and III) or NAGA deficiency (types I, II and III) . Characterized by neurologic manifestations that range in severity, Schindler disease type I is the most severe form, followed by type III, which may have mild-to-moderate effects. Schindler disease type II, also known as Kanzaki disease, is characterized by mild intellectual impairment and angiokeratoma corporis diffusum.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: NAGA polyclonal Antibody detects endogenous levels of NAGA protein.

Molecular Weight: ~ 47 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Alpha-galactosidase B; α-galactosidase B; galactosidaseαB; galactosidase-αB;

Immunogen: Recombinant protein of human NAGA.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: