NALP2 Antibody | 3027

NALP2 Antibody | 3027 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: NALP2 antibody was raised against a peptide corresponding to 12 amino acids near the carboxy terminus of human NALP2.
The immunogen is located within the last 50 amino acids of NALP2.

Research Area: Apoptosis, Innate Immunity

Tested Application: E, WB

Application: NALP2 antibody can be used for detection of NALP2 by Western blot at 1 to 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Specificiy: N/A

Positive Control 1: Cat. No. 1216 - PC-3 Cell Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: NALP2 Antibody is immunoaffinity chromatography purified IgG.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: NALP2 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: NALP2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Alternate Name: NALP2 Antibody: NBS1, PAN1, NALP2, PYPAF2, CLR19.9, NBS1, NACHT, LRR and PYD domains-containing protein 2, Nucleotide-binding site protein 1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: NALP2 Antibody: NALP2 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli. Unlike the prototypical NALP protein NALP1, NALP2 only contains a NACHT domain, leucine rich repeat (LRR) , and pyrin-containing domain (PYD) . This protein interacts with the adapter protein ASC in addition to CARD8 and caspase-1 to form an inflammasome with high proIL-1β-processing activity and is thought to function as a modulator of NF-κB and procaspase-1 activation in macrophages. It has also been suggested that NALP2, in addition to other NALP family members, can act as innate sensors of pathogens in a manner similar to the toll-like receptors (TLRs) . At least two alternatively spliced transcript variants encoding distinct isoforms have been found for NALP2.