Nanaomycin A | 2790

Nanaomycin A is a selective DNA methyltransferase 3B (DNMT3B) inhibitor. It induces antiproliferative effects in three different tumor cell lines originating from different tissues. Nanaomycin A treatment reduces the global methylation levels in all three cell lines and reactivates transcription of the RASSF1A tumor suppressor gene.

Nanaomycin A is a selective DNA methyltransferase 3B (DNMT3B) inhibitor. It induces antiproliferative effects in three different tumor cell lines originating from different tissues. Nanaomycin A treatment reduces the global methylation levels in all three cell lines and reactivates transcription of the RASSF1A tumor suppressor gene.

2790 | Nanaomycin A DataSheet

Alternate Name/Synonyms: 2-[(1S, 3R)-9-hydroxy-1-methyl-5,10-dioxo-3,4-dihydro-1H-benzo[g]isochromen-3-yl]acetic acid; Nanafrocin, Nanafrocine, Nanafrocinum, Rosanomycin A

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 52934-83-5

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₄O₆

Molecular Weight: 302.28

Cell-Permeable?: Y

Purity: ≥98% by HPLC

Solubilities: DMSO (~10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective DNA methyltransferase 3B (DNMT3B) inhibitor

MDL Number: N/A

PubChem CID: 40586

SMILES: CC1C2=C(CC(O1)CC(=O)O)C(=O)C3=C(C2=O)C(=CC=C3)O

InChi: InChI=1S/C16H14O6/c1-7-13-10(5-8(22-7)6-12(18)19)15(20)9-3-2-4-11(17)14(9)16(13)21/h2-4,7-8,17H,5-6H2,1H3,(H,18,19)

InChi Key: ZCJHPTKRISJQTN-UHFFFAOYSA-N