Nanos2 Antibody | 4645

Nanos2 Antibody | 4645 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Nanos2 antibody was raised against a 13 amino acid synthetic peptide near the carboxy terminus of the human Nanos2.
The immunogen is located within the last 50 amino acids of Nanos2.

Research Area: Signal Transduction

Tested Application: E, WB

Application: Nanos2 antibody can be used for detection of Nanos2 by Western blot at 2 to 4 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Specificiy: This Nanos2 antibody will not cross-react with either Nanos 1 or Nanos3.

Positive Control 1: Cat. No. 1313 - Human Testis Tissue Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: Nanos2 Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Nanos2 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: Nanos2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Alternate Name: Nanos2 Antibody: NOS2, NOS2, Nanos homolog 2, NOS-2

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Nanos2 Antibody: Nanos is a zinc-finger containing, RNA-binding protein that has been implicated in germ cell development in both invertebrates and vertebrates. In drosophila, Nanos represses apoptosis during development to ensure proper germ-line development. Unlike Nanos1 whose expression in mice is dispensable, the Nanos2 and Nanos3 proteins are required for germ cell development. Nanos2-null primordial germ cells (PGCs) die only in the male gonads and show no defects in females, while Nanos3-null PGCs are lost during the migration stage regardless of sex. Nanos2 and Nanos3 have distinct expression patterns during embryo development, suggesting that these two proteins do not have redundant functions. However, expression of Nanos2 can at least partially replace Nanos3 function in a Nanos3-null background. Nanos3 expression can not rescue Nanos2-null defects.