Natamycin | B2685

Natamycin is a naturally-occurring macrolide polyene antibiotic that acts as an antifungal agent. Natamycin blocks fungal growth by binding specifically to ergosterol with an apparent affinity of ~100 μM, but it does not permeabilize cell membranes as other polyene antibiotics are known to do. Natamycin is also used in the food industry as a preservative.

Natamycin is a naturally-occurring macrolide polyene antibiotic that acts as an antifungal agent. Natamycin blocks fungal growth by binding specifically to ergosterol with an apparent affinity of ~100 μM, but it does not permeabilize cell membranes as other polyene antibiotics are known to do. Natamycin is also used in the food industry as a preservative.

B2685 | Natamycin DataSheet

Alternate Name/Synonyms: Pimaricin,(5R,7R,24S)-22R-[(3S-amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1R,3S,26S-trihydroxy-12R-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.05,7]octacosa-8E,14E,16E,18E,20E-pentaene-25R-carboxylic acid

Appearance: Off-white to pale yellow crystalline powder

Formulation:

CAS Number: 7681-93-8

Structure Available?: TRUE

Peptide sequence: N/A

Salt Form: FALSE

Molecular Formula: C₃₃H₄₇NO₁₃

Molecular Weight: 665.73

Cell-Permeable?: TRUE

Purity: ≥95%

Solubilities: ~ 1 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A polyene antibiotic and an antifungal agent

MDL Number: MFCD00135085

PubChem CID: 5284447

SMILES: CC1CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC3C(O3)C=CC(=O)O1)O)O)O)C(=O)O)OC4C(C(C(C(O4)C)O)N)O

InChi: InChI=1S/C33H47NO13/c1-18-10-8-6-4-3-5-7-9-11-21(45-32-30(39)28(34)29(38)19(2)44-32)15-25-27(31(40)41)22(36)17-33(42,47-25)16-20(35)14-24-23(46-24)12-13-26(37)43-18/h3-9,11-13,18-25,27-30,32,35-36,38-39,42H,10,14-17,34H2,1-2H3,(H,40,41)/b4-3+,7-5+,8-6+,11-9+,13-12+/t18-,19-,20+,21+,22+,23-,24-,25+,27-,28+,29-,30+,32+,33-/m1/s1

InChi Key: NCXMLFZGDNKEPB-FFPOYIOWSA-N