NCB-0846 | B2643

NCB-0846 is a potent small-molecule TNIK (Traf2 and Nck-interacting protein kinase) inhibitor, having anti-Wnt activity and suppressing Wnt-driven intestinal tumorigenesis. Also inhibits FLT3, JAK3, PDGFRa, TRKA, CDK2/CycA2, and HGK. NCB-0846 suppresses the growth of tumors established by inoculating HCT116 cells into immunodeficient mice

NCB-0846 is a potent small-molecule TNIK (Traf2 and Nck-interacting protein kinase) inhibitor, having anti-Wnt activity and suppressing Wnt-driven intestinal tumorigenesis. Also inhibits FLT3, JAK3, PDGFRa, TRKA, CDK2/CycA2, and HGK. NCB-0846 suppresses the growth of tumors established by inoculating HCT116 cells into immunodeficient mice

B2643 | NCB-0846 DataSheet

Alternate Name/Synonyms: cis-4-(2-(3H-Benzo[d]imidazol-5-ylamino)quinazolin-8-yloxy)cyclohexanol

Appearance: Crystalline solid

Formulation:

CAS Number: 1792999-26-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₁N₅O₂

Molecular Weight: 375.42

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >30 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent TNIK inhibitor

MDL Number:

PubChem CID: 91801204

SMILES: C1CC(CCC1O)OC2=CC=CC3=CN=C(N=C32)NC4=CC5=C(C=C4)N=CN5

InChi: InChI=1S/C21H21N5O2/c27-15-5-7-16(8-6-15)28-19-3-1-2-13-11-22-2

InChi Key: FYWRWBSYRGSWIQ-UHFFFAOYSA-N