NCH 51 | B1130

NCH-51 (PTACH) is a cell-permeable prodrug that is intracellularly converted to a potent HDAC inhibitor (IC₅₀ of 48 nM). PTACH is predicted to exhibit a similar HDAC binding mode as that of SAHA, interacting with the active-site zinc targeting group.

NCH-51 (PTACH) is a cell-permeable prodrug that is intracellularly converted to a potent HDAC inhibitor (IC₅₀ of 48 nM). PTACH is predicted to exhibit a similar HDAC binding mode as that of SAHA, interacting with the active-site zinc targeting group.

B1130 | NCH 51 DataSheet

Alternate Name/Synonyms: 2-Methylpropanethioic acid S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester; PTACH; Cpd 51

Appearance: White Solid

Formulation: N/A

CAS Number: 848354-66-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₆N₂O₂S₂

Molecular Weight: 390.56

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>35 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A HDAC inhibitor

MDL Number: MFCD08705329

PubChem CID: 11395181

SMILES: CC(C)C(=O)SCCCCCCC(=O)NC1=NC(=CS1)C2=CC=CC=C2

InChi: InChI=1S/C20H26N2O2S2/c1-15(2)19(24)25-13-9-4-3-8-12-18(23)22-20-21-17(14-26-20)16-10-6-5-7-11-16/h5-7,10-11,14-15H,3-4,8-9,12-13H2,1-2H3,(H,21,22,23)

InChi Key: MDYDGUOQFUQOGE-UHFFFAOYSA-N