NCoA-7 (I454) polyclonal Antibody | BS3356

NCoA-7 (I454) polyclonal Antibody | BS3356 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Nuclear receptors for steroids, thyroid hormones and retinoic acids are ligand-dependent transcription factors that activate transcription through specific DNA binding sites in their target genes. NCoA-7 (nuclear receptor coactivator 7), also known as ESNA1 or ERAP140, is a 942 amino acid nuclear protein that enhances nuclear receptor transcriptional activities and coactivates several nuclear receptors including PPAR©, ERα, TRβ1 and RARα. Highly expressed in brain and weakly expressed in pancreas, bladder, ovary, spinal cord, prostate, mammary gland, ovary, uterus and stomach, NCoA-7 is a member of the OXR1 family and contains one LysM repeat and a TLD domain. Six NCoA-7 isoforms are known to exist due to alternative splicing events, and the gene encoding NCoA-7 maps to human chromosome 6q22.31 and mouse chromosome 10 A4.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: NCoA-7 (I454) pAb detects endogenous levels of NCoA-7 protein.

Molecular Weight: ~ 106 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Nuclear receptor coactivator 7; 140 kDa estrogen receptor-associated protein; Estrogen nuclear receptor coactivator 1; NCOA7; ERAP140; ESNA1; Nbla00052; Nbla10993

Immunogen: Synthetic peptide, corresponding to amino acids 422-470 of Human NCoA-7.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A