NDGA | 2581

NDGA is a a phenolic compound isolated from the creosote bush Larrea divaricatta that has anti-cancer activities both in vitro and in vivo. NDGA acts as a non-selective lipoxygenase (LO) inhibitor (IC₅₀ values are 3.0-5.0 µM for human platelet 12-LO and 0.91 µM for rabbit reticulocyte 15-LO). Also inhibits IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells.

NDGA is a a phenolic compound isolated from the creosote bush Larrea divaricatta that has anti-cancer activities both in vitro and in vivo. NDGA acts as a non-selective lipoxygenase (LO) inhibitor (IC₅₀ values are 3.0-5.0 µM for human platelet 12-LO and 0.91 µM for rabbit reticulocyte 15-LO). Also inhibits IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells.

2581 | NDGA DataSheet

Alternate Name/Synonyms: Nordihydroguaiaretic Acid; 4,4’-(2,3-dimethyl-1,4-butanediyl)bis-1,2-benzenediol

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 500-38-9

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₂₂O₄

Molecular Weight: 302.4

Cell-Permeable?: Yes

Purity: ≥97% by HPLC

Solubilities: DMSO (~100 mg/ml) or EtOH (~ 100 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A lipoxygenase (LO) inhibitor

MDL Number: MFCD00002206

PubChem CID: 4534

SMILES: CC(CC1=CC(=C(C=C1)O)O)C(C)CC2=CC(=C(C=C2)O)O

InChi: InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3

InChi Key: HCZKYJDFEPMADG-UHFFFAOYSA-N