NECA | B2262

NECA is a high affinity adenosine receptor agonist (Ki values are 6.2, 14, and 20 nM for human A3, A1 and A2A receptors respectively; EC₅₀ = 2.4 μM for human A2B). NECA is also reported to act as a potent vasodilator and can inhibit platelet aggregation by increasing cAMP (EC₅₀ = 3.1 µM).

NECA is a high affinity adenosine receptor agonist (Ki values are 6.2, 14, and 20 nM for human A3, A1 and A2A receptors respectively; EC₅₀ = 2.4 μM for human A2B). NECA is also reported to act as a potent vasodilator and can inhibit platelet aggregation by increasing cAMP (EC₅₀ = 3.1 µM).

B2262 | NECA DataSheet

Alternate Name/Synonyms: 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-β-D-ribofuranuronamide; 5'-N-Ethylcarboxamidoadenosine

Appearance: White solid

Formulation: N/A

CAS Number: 35920-39-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₂H₁₆N₆O₄

Molecular Weight: 308.3

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A high affinity adenosine receptor agonist

MDL Number: MFCD00069195

PubChem CID: 448222

SMILES: CCNC(=O)C1C(C(C(O1)N2C=NC3=C2N=CN=C3N)O)O

InChi: InChI=1S/C12H16N6O4/c1-2-14-11(21)8-6(19)7(20)12(22-8)18-4-17-5-9(13)15-3-16-10(5)18/h3-4,6-8,12,19-20H,2H2,1H3,(H,14,21)(H2,13,15,16)/t6-,7+,8-,12+/m0/s1

InChi Key: JADDQZYHOWSFJD-FLNNQWSLSA-N