NEDD4 polyclonal Antibody | BS70345

NEDD4 polyclonal Antibody | BS70345 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB IHC

Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200

Background: NEDD4 is a 221 amino acid, Golgi-associated protein which contains three transmembrane domains in its carboxy-terminus and two PY motifs in its amino-terminus. NEDD4 may play a role in Golgi structure and function. It binds the WW domains of a number of NEDD4 family members called HECT-type E3 ubiquitin ligases. NEDD4 is strongly expressed in surviving neurons around an injury site, which suggests that ubiquitination may be a possible survival strategy and that NEDD4 may act as a neuroprotective protein. It may also have an effect on the function of Itch, another E3 ubiquitin ligase. Expression of NEDD4 and its association with Itch may be promoted by T cell activation.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: NEDD4 polyclonal Antibody detects endogenous levels of NEDD4 protein.

Molecular Weight: ~ 120 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: NEDD-4; NEDD4; KIAA0093; NEDD4-1; PIG53

Immunogen: Recombinant protein of human NEDD4.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: