NEK1 Antibody (C-term) [APR06061G]

NEK1 Antibody (C-term) [APR06061G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This NEK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1165-1196 amino acids from the C-terminal region of human NEK1.

Cellular Localisation: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P51954}. Cytoplasm. Note=Associated with the pericentriolar material (PubMed:21211617) . Localizes to centrosome during interphase and mitosis (By similarity) . Translocated from cytoplasm to discrete nuclear foci at sites of DNA damage (PubMed:15604234) {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:15604234, ECO:0000269|PubMed:21211617}

Molecular Weight: 142828

Clone: Polyclonal

Gene Name: NEK1

Gene ID: 4750

Function: Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784) . Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784) . In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784) . May be implicated in the control of meiosis (By similarity) . Involved in cilium assembly (PubMed:21211617) .

Summary: Tissue Location: High fetal expression in the brain and kidney.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: IHC-P, WB

Dilution: WB--1:500 IHC-P--1:100~500

Synonyms: Serine/threonine-protein kinase Nek1, Never in mitosis A-related kinase 1, NimA-related protein kinase 1, Renal carcinoma antigen NY-REN-55, NEK1, KIAA1901