Nek2/Hec1 inhibitor | B2924

Nek2/Hec1 inhibitor targets the Hec1/Nek2 pathway and causes chromosome mis-alignment as well as cell death. The IC₅₀ for cytotoxicity in MDA-MB231, MDA-MB468, HeLa and K562 cell lines is 1.1 μM, 3.4 μM,1.6 μM and 1.2 μM respectively.

Nek2/Hec1 inhibitor targets the Hec1/Nek2 pathway and causes chromosome mis-alignment as well as cell death. The IC₅₀ for cytotoxicity in MDA-MB231, MDA-MB468, HeLa and K562 cell lines is 1.1 μM, 3.4 μM,1.6 μM and 1.2 μM respectively.

B2924 | Nek2/Hec1 inhibitor DataSheet

Alternate Name/Synonyms: N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]-4-pyridinecarboxamide; N-[4-(2,4-Dimethylphenyl)thiazol-2-yl]isonicotinamide

Appearance: Solid

Formulation:

CAS Number: 560103-80-2

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₁₇H₁₅N₃OS

Molecular Weight: 309.39

Cell-Permeable?: True

Purity: 97%

Solubilities: Soluble in in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of Nek2/Hec1

MDL Number: MFCD03384899

PubChem CID: 4363180

SMILES: O=C(C1=CC=NC=C1)NC2=NC(C3=CC=C(C)C=C3C)=CS2

InChi: InChI=1S/C17H15N3OS/c1-11-3-4-14(12(2)9-11)15-10-22-17(19-15)20-16(21)13-5-7-18-8-6-13/h3-10H,1-2H3,(H,19,20,21)

InChi Key: IBQLKKBLBXJSGU-UHFFFAOYSA-N