Neomycin sulfate | 9620

Neomycin sulfate is a broad spectrum aminoglycoside antibiotic composed of a number of related neomycin compounds including neomycin A (neamine), neomycin B (framycetin), neomycin C, and a few minor compounds found in much lower quantities. Neomycin B is the most active component in neomycin followed by neomycin C and neomycin A. This product acts by binding to the 30S and 50S subunits, causing miscoding and inhibiting initiation and elongation during protein synthesis. Neomycin also blocks voltage-sensitive Ca²⁺+ channels without affecting the Na⁺/Ca²⁺ antiporter in neurons.

Neomycin sulfate is a broad spectrum aminoglycoside antibiotic composed of a number of related neomycin compounds including neomycin A (neamine), neomycin B (framycetin), neomycin C, and a few minor compounds found in much lower quantities. This product acts by binding to the 30S and 50S subunits, causing miscoding and inhibiting initiation and elongation during protein synthesis. Neomycin also blocks voltage-sensitive Ca²⁺ channels without affecting the Na⁺/Ca²⁺ antiporter in neurons.

9620 | Neomycin sulfate DataSheet

Alternate Name/Synonyms: 5-amino-2-(aminomethyl)-6-[4,6-diamino-2-[4-[3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol;sulfuric acid

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1405-10-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₄₆N₆O₁₃·3H₂SO4

Molecular Weight: 908.9

Cell-Permeable?: Yes

Purity: ≥90%

Solubilities: H₂O (~50 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: Abroad spectrum aminoglycoside antibiotic

MDL Number: MFCD00077833

PubChem CID: 44134844

SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O.OS(=O)(=O)O.OS(=O)(=O)O

InChi: InChI=1S/C23H46N6O13.3H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;3*1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;3*(H2,1,2,3,4)

InChi Key: KWBUARAINLGYMG-UHFFFAOYSA-N