NEURL Antibody (Center) [AMM06621G]

NEURL Antibody (Center) [AMM06621G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This NEURL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 158-186 amino acids from the Central region of human NEURL.

Cellular Localisation: Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein Perikaryon. Cell projection, dendrite. Cell junction, synapse, postsynaptic density. Note=Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites. Colocalized with PSD95 in postsynaptic sites Colocalized with CPEB3 at apical dendrites of CA1 neurons (By similarity) . Colocalized with JAG1 at the cell surface.

Molecular Weight: 61860

Clone: Polyclonal

Gene Name: NEURL1

Gene ID: 9148

Function: Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.

Summary: Tissue Location: Expressed in brain, testis, pituitary gland, pancreas and bone marrow. Also poorly expressed in malignant astrocytomas and several neuroectodermal tumor cell lines. Weakly expressed in medulloblastoma (MB) compared with normal cerebellar tissues.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: E3 ubiquitin-protein ligase NEURL1, 632-, Neuralized-like protein 1A, h-neu, h-neuralized 1, RING finger protein 67, NEURL1, NEURL, NEURL1A, RNF67