Neurodazine | 2568

Cell-permeable. A promoter of neurogenesis. Neurodazine induces neuronal differentiation in skeletal muscle cells. In mouse C2C12 myoblasts, neurodazine (2 μM for seven days) upregulated the expression of neuron-specific enolase (NSE), neurofilament 200 (NF200), synapsin, and other neuronal markers. Neurodazine similarly upregulated NSE and NF200 in human skeletal muscle fibers, indicating efficacy in mature muscle as well as in myoblasts.

Neurodazine is a promoter of neurogenesis. Neurodazine induces neuronal differentiation in skeletal muscle cells. In mouse C2C12 myoblasts, neurodazine (2 μM for seven days) upregulated the expression of neuron-specific enolase (NSE), neurofilament 200 (NF200), synapsin, and other neuronal markers.

2568 | Neurodazine DataSheet

Alternate Name/Synonyms: 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, methyl, 1-methylester diester

Appearance: Off-white solid

Formulation: N/A

CAS Number: 937807-66-4

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₂₁ClN₂O₃

Molecular Weight: 456.92

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~30 mg/ml) or EtOH (~ 8 mg/ml

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A promoter of neurogenesis

MDL Number: MFCD08906055

PubChem CID: 16112820

SMILES: COC1=CC=C(C=C1)C2=C(N=C(N2)C3=CC=C(O3)C4=CC(=CC=C4)Cl)C5=CC=C(C=C5)OC

InChi: InChI=1S/C27H21ClN2O3/c1-31-21-10-6-17(7-11-21)25-26(18-8-12-22(32-2)13-9-18)30-27(29-25)24-15-14-23(33-24)19-4-3-5-20(28)16-19/h3-16H,1-2H3,(H,29,30)

InChi Key: FEEOFPAEDSMOTO-UHFFFAOYSA-N